The effects of theophylline on 661-1661-1661-1on polymorphonuclear leukocytes of asthmatic children and juveniles
Identifieur interne : 003054 ( Main/Exploration ); précédent : 003053; suivant : 003055The effects of theophylline on 661-1661-1661-1on polymorphonuclear leukocytes of asthmatic children and juveniles
Auteurs : J. Otto [Allemagne] ; S. Günther [Allemagne] ; R. Urbanek [Allemagne]Source :
- European Journal of Pediatrics [ 0340-6199 ] ; 1990-06-01.
English descriptors
- KwdEn :
- Teeft :
- Adrenergic, Adrenergic receptors, Adrenergic therapy, Asthma, Asthmatic, Asthmatic children, Asthmatic subjects, Bmax, Bronchial asthma, Federal republic, Icyp, Leukocyte, Lymphocyte, Medication, Polymorphonuclear, Polymorphonuclear leukocytes, Present study, Previous studies, Receptor, Receptor density, Significant differences, Theophylline, Theophylline therapy.
Abstract
Abstract: The density (Bmax) and affinity (KD) of β2-adrenoceptors in polymorphonuclear leukocytes (PMN) were measured in 29 children and juveniles with mild or moderate asthma and in 25 healthy control subjects using the highly specific radioligand (±)-125I-cyanopindolol. No significant difference in Bmax was found between asthmatic subjects without medication and the control group. The asthmatic subjects were divided into four different groups by their actual medication: no medication, adrenergics, theophylline, adrenergics plus theophylline. Analysis of variance revealed highly significant differences between these groups for Bmax (P=0.0016) but not for KD. In asthmatics on adrenergic therapy Bmax was significantly lower (995±415) than in asthmatics without medication (1660±521;P=0.008). In contrast, Bmax in asthmatics on theophylline therapy was significantly higher (2137±231;P=0.009) than in the controls. Bmax was average in the group of asthmatics treated with both adrenergics and theophylline (1619±547). It is concluded that in asthmatic subjects therapy with theophylline increases the density of β2-adrenoceptors and partly prevents their down-regulation induced by adrenergic therapy.
Url:
DOI: 10.1007/BF02034759
Affiliations:
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No significant difference in Bmax was found between asthmatic subjects without medication and the control group. The asthmatic subjects were divided into four different groups by their actual medication: no medication, adrenergics, theophylline, adrenergics plus theophylline. Analysis of variance revealed highly significant differences between these groups for Bmax (P=0.0016) but not for KD. In asthmatics on adrenergic therapy Bmax was significantly lower (995±415) than in asthmatics without medication (1660±521;P=0.008). In contrast, Bmax in asthmatics on theophylline therapy was significantly higher (2137±231;P=0.009) than in the controls. Bmax was average in the group of asthmatics treated with both adrenergics and theophylline (1619±547). 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